Effects of Direction Time Constraints and Walking Speed on Turn Strategies and Gait Adaptations in Healthy Older and Young Adults

Hip fractures can be life-threatening, debilitating, and costly. The odds for hip fracture increases from impact of sideways falls. While turning has been strongly associated with hip fracture & sideways falls, the distinction between the risks for walking-turns as opposed to low-velocity in-place turning is not clear. The present study sought to fill a gap as previous research had not compared walking-turn performance in young & healthy older adults at low-fall risk within the same study and response-conditions of speed interacting with direction-cue time constraints. Spatial-temporal variables representative of AP braking/propulsion (i.e. stride-length & speed) & ML stability (left/right H-H BOS) were collected with the Gaitrite upon approach of a turning zone whose entrance width was just 73 cm; and turn-strategy categorical data for stable wide-BOS step-turns, biomechanically challenging narrow-BOS spin-turns, and combined subtypes of mixed-turns either of the “extra-step” variety representative of an AP stability/braking issue or “small-amplitude” variety representative of a ML stability/balance issue were captured on video. Mixed-ANOVA of gait measures for AP propulsion/braking revealed no age-group differences in speed despite a trend for less of a fast-pace increase in elderly stride-length, yet similar anticipatory slowing and shorter strides approaching turns. Measures of ML stability revealed similar anticipatory widening of right BOS approaching turns, and a three-way interaction showed both had similar anticipatory narrowing of left BOS when approaching turns at fast-pace and similar reactive narrowing of left BOS following an unexpected turn-cue at preferred pace. Loglinear analysis of turn-strategies revealed no age-related associations as both preferred mixed-turns the least. At fast speeds preference for spin-turns decreased, yet when late-cued preference for both step-turns and spin-turns decreased 5.5-fold & 4.0-fold, respectively, indicating other factors besides biomechanical. Furthermore, the standardized residual reached significance for the elderly mixed-turns cell at the most constrained fast-speed*late-cue response-condition, with the “extra-step” sub-type contributing greatest possibly implying an AP rather than ML stability issue. The findings suggest that when approaching turns across an interaction of response-time conditions, healthy older adults show similar anticipatory/reactive gait adaptations and turn-strategy preferences with regards to AP propulsion/deceleration and ML stability/balance. In conclusion, within study limits, fall-prevention gait-training for healthy elderly with low-fall-risk and no age-related speed declines, in addition to addressing important ML stability issues of turn execution, are best served by not losing sight of the fundamental prerequisite to arrest forward momentum upon approach, and being inclusive of spin-turns for their ML space-efficiency

Effects of Direction Time Constraints and Walking Speed on Turn Strategies and Gait Adaptations in Healthy Older and Young Adults

Hip fractures can be life-threatening, debilitating, and costly. The odds for hip fracture increases from impact of sideways falls. While turning has been strongly associated with hip fracture & sideways falls, the distinction between the risks for walking-turns as opposed to low-velocity in-place turning is not clear. The present study sought to fill a gap as previous research had not compared walking-turn performance in young & healthy older adults at low-fall risk within the same study and response-conditions of speed interacting with direction-cue time constraints. Spatial-temporal variables representative of AP braking/propulsion (i.e. stride-length & speed) & ML stability (left/right H-H BOS) were collected with the Gaitrite upon approach of a turning zone whose entrance width was just 73 cm; and turn-strategy categorical data for stable wide-BOS step-turns, biomechanically challenging narrow-BOS spin-turns, and combined subtypes of mixed-turns either of the “extra-step” variety representative of an AP stability/braking issue or “small-amplitude” variety representative of a ML stability/balance issue were captured on video. Mixed-ANOVA of gait measures for AP propulsion/braking revealed no age-group differences in speed despite a trend for less of a fast-pace increase in elderly stride-length, yet similar anticipatory slowing and shorter strides approaching turns. Measures of ML stability revealed similar anticipatory widening of right BOS approaching turns, and a three-way interaction showed both had similar anticipatory narrowing of left BOS when approaching turns at fast-pace and similar reactive narrowing of left BOS following an unexpected turn-cue at preferred pace. Loglinear analysis of turn-strategies revealed no age-related associations as both preferred mixed-turns the least. At fast speeds preference for spin-turns decreased, yet when late-cued preference for both step-turns and spin-turns decreased 5.5-fold & 4.0-fold, respectively, indicating other factors besides biomechanical. Furthermore, the standardized residual reached significance for the elderly mixed-turns cell at the most constrained fast-speed*late-cue response-condition, with the “extra-step” sub-type contributing greatest possibly implying an AP rather than ML stability issue. The findings suggest that when approaching turns across an interaction of response-time conditions, healthy older adults show similar anticipatory/reactive gait adaptations and turn-strategy preferences with regards to AP propulsion/deceleration and ML stability/balance. In conclusion, within study limits, fall-prevention gait-training for healthy elderly with low-fall-risk and no age-related speed declines, in addition to addressing important ML stability issues of turn execution, are best served by not losing sight of the fundamental prerequisite to arrest forward momentum upon approach, and being inclusive of spin-turns for their ML space-efficiency

Propuesta de implementación de un modelo de gestión de la calidad basado en la norma ISO 9001:2008 (2015) para microempresas comerciales familiares en el Distrito Metropolitano de Quito

En el presente estudio se determinan los lineamientos de un modelo de gestión de la calidad, basado en la norma internacional ISO 9001:2008, que atienda a las características particulares de las microempresas comercializadoras familiares en la ciudad de Quito. Con este fin, a través de un estudio de tipo exploratorio y descriptivo que consideró fuentes primarias y secundarias, se determinaron las características de las microempresas y si han adoptado acciones establecidas por un modelo de gestión de la calidad. Como principales conclusiones se pudo verificar que las microempresas familiares no cuentan con un modelo sólido de gestión de la calidad, aunque sí desarrollan algunos de los principios de la familia de normas ISO 9000 y requisitos de la norma ISO 9001, al menos de una manera informal; adicionalmente se concluyó que es posible implementar varias de las acciones establecidas por la norma con el fin de beneficiar a estas microempresas y generar condiciones óptimas para su perdurabilidad y crecimiento

Paraxial and nonparaxial polynomial beams and the analytic approach to propagation

We construct solutions of the paraxial and Helmholtz equations which are polynomials in their spatial variables. These are derived explicitly using the angular spectrum method and generating functions. Paraxial polynomials have the form of homogeneous Hermite and Laguerre polynomials in Cartesian and cylindrical coordinates respectively, analogous to heat polynomials for the diffusion equation. Nonparaxial polynomials are found by substituting monomials in the propagation variable $z$ with reverse Bessel polynomials. These explicit analytic forms give insight into the mathematical structure of paraxially and nonparaxially propagating beams, especially in regards to the divergence of nonparaxial analogs to familiar paraxial beams.Comment: 3 pages, Optics Letters styl

ESTimating plant phylogeny: lessons from partitioning

BACKGROUND: While Expressed Sequence Tags (ESTs) have proven a viable and efficient way to sample genomes, particularly those for which whole-genome sequencing is impractical, phylogenetic analysis using ESTs remains difficult. Sequencing errors and orthology determination are the major problems when using ESTs as a source of characters for systematics. Here we develop methods to incorporate EST sequence information in a simultaneous analysis framework to address controversial phylogenetic questions regarding the relationships among the major groups of seed plants. We use an automated, phylogenetically derived approach to orthology determination called OrthologID generate a phylogeny based on 43 process partitions, many of which are derived from ESTs, and examine several measures of support to assess the utility of EST data for phylogenies. RESULTS: A maximum parsimony (MP) analysis resulted in a single tree with relatively high support at all nodes in the tree despite rampant conflict among trees generated from the separate analysis of individual partitions. In a comparison of broader-scale groupings based on cellular compartment (ie: chloroplast, mitochondrial or nuclear) or function, only the nuclear partition tree (based largely on EST data) was found to be topologically identical to the tree based on the simultaneous analysis of all data. Despite topological conflict among the broader-scale groupings examined, only the tree based on morphological data showed statistically significant differences. CONCLUSION: Based on the amount of character support contributed by EST data which make up a majority of the nuclear data set, and the lack of conflict of the nuclear data set with the simultaneous analysis tree, we conclude that the inclusion of EST data does provide a viable and efficient approach to address phylogenetic questions within a parsimony framework on a genomic scale, if problems of orthology determination and potential sequencing errors can be overcome. In addition, approaches that examine conflict and support in a simultaneous analysis framework allow for a more precise understanding of the evolutionary history of individual process partitions and may be a novel way to understand functional aspects of different kinds of cellular classes of gene products

Glycosylated BODIPY- Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy

Pt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with the photocytotoxicity of BODIPYs. Additional conjugation with targeting ligands can boost the uptake by cancer cells that overexpress the corresponding receptors. We describe two Pt(II) triangles, 1 and 2, built with pyridyl BODIPYs functionalized with glucose (3) or triethylene glycol methyl ether (4), respectively. Both 1 and 2 showed higher singlet oxygen quantum yields than 3 and 4, due to the enhanced singlet-to-triplet intersystem crossing. To evaluate the targeting effect of the glycosylated derivative, in vitro experiments were performed using glucose transporter 1 (GLUT1)-positive HT29 and A549 cancer cells, and noncancerous HEK293 cells as control. Both 1 and 2 showed higher cellular uptake than 3 and 4. Specifically, 1 was selective and highly cytotoxic toward HT29 and A549 cells. The synergistic chemo- and photodynamic behavior of the metallacycles was also confirmed. Notably, 1 exhibited superior efficacy toward the cisplatin-resistant R-HepG2 cellsFinancial support from Spanish MINECO (PID2020- 116490GB-I00 and PID2020-115801RB-C21) is acknowledged. We also thank financial support to the Comunidad de Madrid (MAD2D-CM) and MICINN (“Planes complementarios, Materiales Avanzados”). IMDEA Nanociencia acknowledges support from the “Severo Ochoa” Program for Centres of Excellence in R&D (MINECO, Grant SEV2016-0686). E.Y.X. thanks The Chinese University of Hong Kong for support through the Impact Postdoctoral Fellowship Schem

Implications for electron acceleration and transport from non-thermal electron rates at looptop and footpoint sources in solar flares

The interrelation of hard X-ray (HXR) emitting sources and the underlying physics of electron acceleration and transport presents one of the major questions in the high energy solar flare physics. Spatially resolved observations of solar flares often demonstrate the presence of well separated sources of bremsstrahlung emission, so-called coronal and foot-point sources. Using spatially resolved X-ray observations by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) and recently improved imaging techniques, we investigate in detail the spatially resolved electron distributions in a few well observed solar flares. The selected flares can be interpreted as having a standard geometry with chromospheric HXR foot-point sources related to thick-target X-ray emission and the coronal sources characterised by a combination of thermal and thin-target bremsstrahlung. Using imaging spectroscopy technique, we deduce the characteristic electron rates and spectral indices required to explain the coronal and foot-points X-ray sources. We found that, during the impulsive phase, the electron rate at the loop-top is several times (a factor of 1.7-8) higher than at the foot-points. The results suggest sufficient number of electrons accelerated in the loop-top to explain the precipitation into the foot-points and implies electrons accumulation in the loop-top. We discuss these results in terms of magnetic trapping, pitch-angle scattering and injection properties. Our conclusion is that the accelerated electrons must be subject to magnetic trapping and/or pitch-angle scattering, keeping a fraction of the population trapped inside the coronal loops. These findings put strong constraints on the particle transport in the coronal source, and provide a quantitative limits on deka-keV electron trapping/scattering in the coronal source

Polymer membrane-based ion-, gas- and bio-selective potentiometric sensors

Recent progress in the design of new polymer membrane-based potentiometric ion-, gas- and bio-selective electrodes in chemistry laboratories at the University of Michigan (Ann Arbor) is reviewed. Emphasis is placed on describing the performance of devices for measuring anions (e.g., salicylate, thiocyanate, chloride and heparin) and gases (e.g., ammonia, carbon dioxide and oxygen) in biological samples, both in vitro and in vivo. Beyond direct measurement of key ions and gases in complex matrices, some of the new membrane electrode systems reported can serve as base transducers for the development of biosensors containing integrated biological reagents, including enzymes and antibodies. New approaches for mass fabricating solid-state ion and biosensor devices as well as future directions for research in the entire field of polymer membrane sensors are also described.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31010/1/0000685.pd

The Lantern Vol. 61, No. 2, Summer 1994

• She Was a Woman of Dignity • Retake, Scene 16 • Las Vegas Sweatshirt • Pitcher Hill • In Preparation for Wisdom (Teeth) • Moist Slacks • My Mother\u27s Purse • It Comes and Goes Everyday • The Simplicity of Marriage • The First Performance • Hunger • Pushkin\u27s Dream • Tuesday, October 19 • Poetry of Baseball • Some Things are More Important Than Others • Musician • Of What Befell Our Good Knight • Piranha • Oceans Apart • Brooklyn Cantos • Snowshower • Thankfully in Australia • Toothpaste and Tuna Fish • Living Space • Blue Monday • Afterglow • A Path to Consider • Endless Summer • Scaredy-Cathttps://digitalcommons.ursinus.edu/lantern/1144/thumbnail.jp